Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type
نویسندگان
چکیده
منابع مشابه
Hair follicle dermal cells repopulate the mouse haematopoietic system.
Skin and hair follicle stem cell biology is the focus of increasing interest, not least because the adult hair follicle has well defined dermal and epithelial populations that display distinct developmental properties. Recent evidence suggests that a number of adult cell populations have much broader stem cell capabilities than previously thought. To examine whether this applied to the hair fol...
متن کاملHair follicle dermal papilla cells at a glance.
Ryan R. Driskell1, Carlos Clavel2, Michael Rendl2,* and Fiona M. Watt1,3,* 1Laboratory for Epidermal Stem Cell Biology, Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK 2Black Family Stem Cell Institute and Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA 3CRUK Cambridge Research Institute, ...
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Cells. Human dermal papilla cells isolated from temporal scalp dermis (Promocell, Heidelberg, Germany) from five female donors (HDP41, HDP43, HDP44, HDP47, and HDP52) and one male donor (HDP60), named according to donor age in years, were propagated in vitro according to manufacturer’s recommendations. Keratinocytes were isolated from neonatal foreskins and were cultured in serum-free medium (K...
متن کاملSingle transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
Reprogramming patient-specific somatic cells into induced pluripotent stem (iPS) cells has great potential to develop feasible regenerative therapies. However, several issues need to be resolved such as ease, efficiency, and safety of generation of iPS cells. Many different cell types have been reprogrammed, most conveniently even peripheral blood mononuclear cells. However, they typically requ...
متن کاملAssembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction
Intradermal adipose tissue plays an essential role for hair follicles (HFs) regeneration by regulating hair cycles. However, the effect of reconstruction of HFs and the involvement of adipose-related cells are poorly understood. We investigated assembly strategies for the interactions of dermal papilla (DP) cells with adipose-derived stem cells (ASCs) in promoting hair formation. DP cells lose ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2014
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2014.10.022